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GENERIC NAME: duloxetine Name: generic Cymbalta
DRUG CLASS AND MECHANISM: Duloxetine is really a selective serotonin and norepinephrine reuptake inhibitor (SNRI) for treating depression, panic attack and pain linked to diabetic peripheral neuropathy or fibromyalgia. Other drugs in this class include milnacipran (Savella), venlafaxine (Effexor), and desvenlafaxine (Pristiq). Duloxetine affects neurotransmitters, the chemicals that nerves from the brain make and release so that you can talk to the other person. Neurotransmitters either travel all over the space between nerves and fasten to receptors on the outside of nearby nerves or they connect to receptors on top of the nerves that produced them, to remain taken up by way of the nerve and released again (a procedure referred to as re-uptake).
Most professionals feel that an imbalance among neurotransmitters may be the reason behind depression and also other psychiatric disorders. Serotonin and norepinephrine are a couple of neurotransmitters released by nerves within the brain. Duloxetine operates by preventing the reuptake of serotonin and epinephrine by nerves because they have been released. Since uptake is an important mechanism for removing released neurotransmitters and terminating their actions on adjacent nerves, the lower uptake due to duloxetine raises the effect of serotonin and norepinephrine inside brain. The mechanism responsible for its effectiveness treating pain is just not known but probably is thought to involve its effects on serotonin and norepinephrine with the brain. Duloxetine was authorized by the FDA in August 2004.
PREPARATIONS: Delayed-release capsules: 20, 30, and 60 mg
STORAGE: Capsules must be stored at 70 degrees, between 15 to 30 C (59 to 86 F).
PRESCRIBED FOR: Duloxetine is needed to treat depression, generalized anxiety disorder, and pain linked to diabetic peripheral neuropathy or fibromyalgia.
DOSING: The recommended dose for the depression is 20 or 30 mg two tmes per day or 60 mg once daily. Patients might be began with 30 mg once daily for starterst week ahead of dose is advanced to 60 mg daily. The recommended dose for anxiety, pain attached to diabetic neuropathy or fibromyalgia is 60 mg daily. There's really no evidence that doses more than 60 mg/day provide additional benefits.
DRUG INTERACTIONS: Duloxetine mustn't be utilized in combination with a monoamine oxidase inhibitor (MAOI) like phenelzine (Nardil), tranylcypromine (Parnate), isocarboxazid (Marplan), and selegiline (Eldepryl), or within Fortnight of discontinuing the MAOI. A minimum of 5 days should be allowed after stopping duloxetine before beginning an MAOI. Mixtures of SNRIs and MAOIs can lead to serious, sometimes fatal, reactions including extremely high body temperature, muscle rigidity, rapid fluctuations of heartbeat and hypertension, extreme agitation progressing to delirium, and coma. Similar reactions will occur if duloxetine is mixed with antipsychotics, tricyclic antidepressants and various drugs affecting serotonin inside brain (for example, tryptophan, and sumatriptan (Imitrex).
