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GENERIC NAME: duloxetine High end: generic cymbalta side effects
DRUG CLASS AND MECHANISM: Duloxetine is known as a selective serotonin and norepinephrine reuptake inhibitor (SNRI) utilized by treating depression, panic attack and pain connected to diabetic peripheral neuropathy or fibromyalgia. Other drugs in this class include milnacipran (Savella), venlafaxine (Effexor), and desvenlafaxine (Pristiq). Duloxetine affects neurotransmitters, the harmful chemicals that nerves inside brain make and release for you to communicate with one another. Neurotransmitters either travel all over the space between nerves and fix to receptors on the top of nearby nerves or they adhere to receptors on top of the nerves that produced them, to become taken up from the nerve and released again (an activity referred to as re-uptake).
Most pros think that an imbalance among neurotransmitters will be the reason for depression and various psychiatric disorders. Serotonin and norepinephrine are a couple of neurotransmitters released by nerves inside brain. Duloxetine heats up preventing the reuptake of serotonin and epinephrine by nerves since they have been released. Since uptake is an essential mechanism for removing released neurotransmitters and terminating their actions on adjacent nerves, the fewer uptake due to duloxetine increases the effect of serotonin and norepinephrine within the brain. The mechanism the cause of its effectiveness treating pain isn't known as well as is thought to involve its effects on serotonin and norepinephrine during the brain. Duloxetine was approved by the FDA in August 2004.
PREPARATIONS: Delayed-release capsules: 20, 30, and 60 mg
STORAGE: Capsules needs to be stored at 70 degrees, between 15 to 30 C (59 to 86 F).
PRESCRIBED FOR: Duloxetine can be used to treat depression, generalized anxiety, and pain linked to diabetic peripheral neuropathy or fibromyalgia.
DOSING: The recommended dose for the treatment of depression is 20 or 30 mg twice daily or 60 mg once daily. Patients can be started with 30 mg once daily first week prior to a dose is advanced to 60 mg daily. The recommended dose for panic attack, pain regarding diabetic neuropathy or fibromyalgia is 60 mg daily. You cannot find any evidence that doses in excess of 60 mg/day provide additional benefits.
DRUG INTERACTIONS: Duloxetine should not be used in combination with a monoamine oxidase inhibitor (MAOI) including phenelzine (Nardil), tranylcypromine (Parnate), isocarboxazid (Marplan), and selegiline (Eldepryl), or within A fortnight of discontinuing the MAOI. At a minimum Five days should really be allowed after stopping duloxetine before beginning an MAOI. Mixtures of SNRIs and MAOIs may result in serious, sometimes fatal, reactions including great temperature, muscle rigidity, rapid fluctuations of heart rate and hypotension, extreme agitation progressing to delirium, and coma. Similar reactions can happen if duloxetine is mixed with antipsychotics, tricyclic antidepressants as well as other drugs that affect serotonin with the brain (including, tryptophan, and sumatriptan (Imitrex).
